Scientific References

The scientific evidence for MSCopilot® is organised by clinical study. Each study groups its associated publications and communications, clearly distinguishing peer-reviewed articles from conference communications.

MSCopilot® pivotal clinical validation study

Multicentre, randomised, crossover study comparing MSCopilot® to reference clinical tests (MSFC) in people with MS. The acceptability of the app in clinical practice was also assessed.

Completed studyRegistry: NCT03148938

Publications & communications

Peer-reviewed article

Maillart E, et al.

MSCopilot, a new multiple sclerosis self-assessment digital solution: results of a comparative study versus standard tests

European Journal of Neurology. 2020;27(3):429-436

Core peer-reviewed validation reference. Multicentre, randomised, crossover study comparing MSCopilot® to standard MS tests (MSFC). AUC of 0.92 (vs 0.89 for MSFC), sensitivity of 81% and specificity of 82% for identification of patients with EDSS > 3.5. Assessment of reliability and reproducibility.

DOI: 10.1111/ene.14091PMID: 31538396PubMed

Peer-reviewed article

Tanoh IC, et al.

Exploring the relationship between MSCopilot, a multidimensional patient self-assessment digital solution, and the Expanded Disability Status Scale

Multiple Sclerosis and Related Disorders. 2021;55:103164

Main EDSS-alignment reference. Correlation of MSCopilot® scores with EDSS (r=0.65). AUC of 0.92 for discrimination of EDSS > 3.5 vs EDSS ≤3.5 patients. Characterisation of disability dimensions: walking, dexterity, cognition and vision.

DOI: 10.1016/j.msard.2021.103164PMID: 34352512PubMed

Conference poster

Maillart E, et al.

MSCopilot®, a new multiple sclerosis self-assessment digital solution: results of a comparative study versus standard tests. A randomized clinical trial

ECTRIMS 2019 / Multiple Sclerosis Journal supplement

Conference communication supporting the Maillart 2020 publication. Description of the multicentre, randomised, crossover design.

View

Conference abstract

Maillart E, et al.

Results of the MSCopilot Study

AAN 2019, P3.2-012

Conference communication documenting early scientific presentations of the pivotal validation study.

View

Conference abstract

Maillart E, et al.

Acceptability in clinical practice of MSCopilot, a smartphone application for digital self-assessment of patients living with multiple sclerosis

ECTRIMS 2018, P702

Majority of respondents favourable to the use of the app in MS care. Marked preference for digital tests over standard tests.

View

MS-DETECT — Early detection of MS progression

International, multicentre, prospective, longitudinal study evaluating MSCopilot® Detect in real-world at-home conditions for detecting disability worsening (target: 336 participants, >35 sites, 7 countries, 18–24 month follow-up).

Ongoing studyRegistry: NCT05816122

Publications & communications

Oral communication

Vermersch P, et al.

Correlation of real-world digital biomarkers with clinical standards, findings from the MS-DETECT study

EAN 2026, Genève (A-26-17831)

1-year longitudinal interim analysis. In 244 participants, MSCopilot® composite scores measured in-clinic (r=0.71) and at home (r=0.71–0.74; p<0.001) correlated with MSFC-4, and the correlation was maintained over time.

View

Conference poster

Graves JS, et al.

Concurrent Validity of MSCopilot® Digital Biomarkers in Real-world Settings Within the MS-DETECT Study

ACTRIMS Forum 2026, P173

Concurrent validity of digital biomarkers in real-world settings. Moderate-to-strong correlations with MSFC-4 components.

View

Conference poster

Vermersch P, et al.

MSCopilot® digital biomarkers obtained in a real-world setting correlated with their clinical counterparts in the MS-DETECT study

ECTRIMS 2025, P1583

Interim analysis: correlation of at-home MSCopilot® digital biomarkers with their MSFC-4 clinical counterparts.

View

MS-FLOWER — Integration of MSCopilot into routine clinical care

US multicentre, prospective pilot study (4 centres, 8 MS specialists, 62 patients; 6-month follow-up) evaluating the feasibility, usability and integration of MSCopilot® into routine clinical care.

Completed studyRegistry: NCT06922942

Publications & communications

Conference poster

Freeman L, et al.

MS-FLOWER, an Ongoing U.S. Multicenter Pilot Study to identify challenges to MSCopilot®'s integration into Multiple Sclerosis standard clinical care

EAN 2026, Genève — ePoster (EPO-0987)

Interim analysis of a feasibility pilot study (4 US centres, 8 specialists, 62 patients). After training, all healthcare providers felt confident introducing MSCopilot® (75% in 5 minutes or less), and all patients surveyed after inclusion found it easy to use.

View

Promotional claims should be supported by objective and verifiable data. Peer-reviewed articles are preferred over conference communications.

Back to home

Scientific References

MSCopilot® pivotal clinical validation study

Multicentre, randomised, crossover study comparing MSCopilot® to reference clinical tests (MSFC) in people with MS. The acceptability of the app in clinical practice was also assessed.

Completed studyRegistry: NCT03148938

Publications & communications

Peer-reviewed article

Maillart E, et al.

MSCopilot, a new multiple sclerosis self-assessment digital solution: results of a comparative study versus standard tests

European Journal of Neurology. 2020;27(3):429-436

DOI: 10.1111/ene.14091PMID: 31538396PubMed

Peer-reviewed article

Tanoh IC, et al.

Exploring the relationship between MSCopilot, a multidimensional patient self-assessment digital solution, and the Expanded Disability Status Scale

Multiple Sclerosis and Related Disorders. 2021;55:103164

DOI: 10.1016/j.msard.2021.103164PMID: 34352512PubMed

Conference poster

Maillart E, et al.

MSCopilot®, a new multiple sclerosis self-assessment digital solution: results of a comparative study versus standard tests. A randomized clinical trial

ECTRIMS 2019 / Multiple Sclerosis Journal supplement

Conference communication supporting the Maillart 2020 publication. Description of the multicentre, randomised, crossover design.

View

Conference abstract

Maillart E, et al.

Results of the MSCopilot Study

AAN 2019, P3.2-012

Conference communication documenting early scientific presentations of the pivotal validation study.

View

Conference abstract

Maillart E, et al.

Acceptability in clinical practice of MSCopilot, a smartphone application for digital self-assessment of patients living with multiple sclerosis

ECTRIMS 2018, P702

Majority of respondents favourable to the use of the app in MS care. Marked preference for digital tests over standard tests.

View

MS-DETECT — Early detection of MS progression

Ongoing studyRegistry: NCT05816122

Publications & communications

Oral communication

Vermersch P, et al.

Correlation of real-world digital biomarkers with clinical standards, findings from the MS-DETECT study

EAN 2026, Genève (A-26-17831)

View

Conference poster

Graves JS, et al.

Concurrent Validity of MSCopilot® Digital Biomarkers in Real-world Settings Within the MS-DETECT Study

ACTRIMS Forum 2026, P173

Concurrent validity of digital biomarkers in real-world settings. Moderate-to-strong correlations with MSFC-4 components.

View

Conference poster

Vermersch P, et al.

MSCopilot® digital biomarkers obtained in a real-world setting correlated with their clinical counterparts in the MS-DETECT study

ECTRIMS 2025, P1583

Interim analysis: correlation of at-home MSCopilot® digital biomarkers with their MSFC-4 clinical counterparts.

View

MS-FLOWER — Integration of MSCopilot into routine clinical care

US multicentre, prospective pilot study (4 centres, 8 MS specialists, 62 patients; 6-month follow-up) evaluating the feasibility, usability and integration of MSCopilot® into routine clinical care.

Completed studyRegistry: NCT06922942

Publications & communications

Conference poster

Freeman L, et al.

MS-FLOWER, an Ongoing U.S. Multicenter Pilot Study to identify challenges to MSCopilot®'s integration into Multiple Sclerosis standard clinical care

EAN 2026, Genève — ePoster (EPO-0987)

View

Promotional claims should be supported by objective and verifiable data. Peer-reviewed articles are preferred over conference communications.

Scientific References

Clinical studies

MSCopilot® pivotal clinical validation study

MSCopilot, a new multiple sclerosis self-assessment digital solution: results of a comparative study versus standard tests

Exploring the relationship between MSCopilot, a multidimensional patient self-assessment digital solution, and the Expanded Disability Status Scale

MSCopilot®, a new multiple sclerosis self-assessment digital solution: results of a comparative study versus standard tests. A randomized clinical trial

Results of the MSCopilot Study

Acceptability in clinical practice of MSCopilot, a smartphone application for digital self-assessment of patients living with multiple sclerosis

MS-DETECT — Early detection of MS progression

Correlation of real-world digital biomarkers with clinical standards, findings from the MS-DETECT study

Concurrent Validity of MSCopilot® Digital Biomarkers in Real-world Settings Within the MS-DETECT Study

MSCopilot® digital biomarkers obtained in a real-world setting correlated with their clinical counterparts in the MS-DETECT study

MS-FLOWER — Integration of MSCopilot into routine clinical care

MS-FLOWER, an Ongoing U.S. Multicenter Pilot Study to identify challenges to MSCopilot®'s integration into Multiple Sclerosis standard clinical care

Scientific References

Clinical studies

MSCopilot® pivotal clinical validation study

MSCopilot, a new multiple sclerosis self-assessment digital solution: results of a comparative study versus standard tests

Exploring the relationship between MSCopilot, a multidimensional patient self-assessment digital solution, and the Expanded Disability Status Scale

MSCopilot®, a new multiple sclerosis self-assessment digital solution: results of a comparative study versus standard tests. A randomized clinical trial

Results of the MSCopilot Study

Acceptability in clinical practice of MSCopilot, a smartphone application for digital self-assessment of patients living with multiple sclerosis

MS-DETECT — Early detection of MS progression

Correlation of real-world digital biomarkers with clinical standards, findings from the MS-DETECT study

Concurrent Validity of MSCopilot® Digital Biomarkers in Real-world Settings Within the MS-DETECT Study

MSCopilot® digital biomarkers obtained in a real-world setting correlated with their clinical counterparts in the MS-DETECT study

MS-FLOWER — Integration of MSCopilot into routine clinical care

MS-FLOWER, an Ongoing U.S. Multicenter Pilot Study to identify challenges to MSCopilot®'s integration into Multiple Sclerosis standard clinical care